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1

Bioactivity and gene expression profiles of hiPSC-generated retinal ganglion cells in MT-ND4 mutated Leber's hereditary optic neuropathy

Wu, You-Ren, Wang, An-Guor, Chen, Yan-Ting, Yarmishyn, Aliaksandr A., Buddhakosai, Waradee, Yang, Tien-Chun, Hwang, De-Kuang, Yang, Yi-Ping, Shen, Chia-Ning, Lee, Hsin-Chen, Chiou, Shih-Hwa, Peng, Chi

Journal:

Experimental Cell Research

Year:

2018

Language:

english

File:

PDF, 1.57 MB

english, 2018

2

Ascorbic acid mitigates the myocardial injury after

Min-Shan Tsai, Chien-Hua Huang, Chia-Ying Tsai, Huei-Wen Chen, Hsin-Chen Lee, Hsaio-Ju Cheng, Chiung-Yuan Hsu, Tzung-Dau Wang, Wei-Tien Chang, Wen-Jone Chen

Journal:

Intensive Care Medicine

Year:

2011

Language:

english

File:

PDF, 1.38 MB

english, 2011

3

Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging

Hsin-Chen Lee, Yau-Huei Wei

Journal:

Year:

2001

Language:

english

File:

PDF, 187 KB

english, 2001

4

Somatic mutations of mitochondrial DNA in aging and cancer progression

Hsin-Chen Lee, Chia-Ming Chang, Chin-Wen Chi

Journal:

Ageing Research Reviews

Year:

2010

Language:

english

File:

PDF, 570 KB

english, 2010

5

Heteroplasmic mutation of mitochondrial DNA D-loop and 4977-bp deletion in human cancer cells during mitochondrial DNA depletion

Hsin-Chen Lee, Li-Sung Hsu, Pen-Hui Yin, Liang-Ming Lee, Chin-Wen Chi

Journal:

Year:

2007

Language:

english

File:

PDF, 474 KB

english, 2007

6

Peroxisome Proliferator-Activated Receptor γ Expression Is Inversely Associated with Macroscopic Vascular Invasion in Human Hepatocellular Carcinoma

Hsu, Hui-Tzu, Sung, Ming-Ta, Lee, Chih-Chun, Kuo, Yin-Ju, Chi, Chin-Wen, Lee, Hsin-Chen, Hsia, Cheng-Yuan

Journal:

International Journal of Molecular Sciences

Year:

2016

Language:

english

File:

PDF, 4.54 MB

english, 2016

7

Independent occurrence of somatic mutations in mitochondrial DNA of human skin from subjects of various ages

Vincent W. S. Liu, Chunfang Zhang, Cheng-Yoong Pang, Hsin-Chen Lee, Ching-You Lu, Yau-Huei Wei, Phillip Nagley

Journal:

Year:

1998

Language:

english

File:

PDF, 174 KB

english, 1998

8

Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer

Chew-Wun Wu, Pen-Hui Yin, Wen-Yi Hung, Anna Fen-Yau Li, Shu-Hui Li, Chin-Wen Chi, Yau-Huei Wei, Hsin-Chen Lee

Journal:

Genes, Chromosomes and Cancer

Year:

2005

Language:

english

File:

PDF, 308 KB

english, 2005

9

Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer

Ling-Ming Tseng, Pen-Hui Yin, Chin-Wen Chi, Chih-Yi Hsu, Chew-Wun Wu, Liang-Ming Lee, Yau-Huei Wei, Hsin-Chen Lee

Journal:

Genes, Chromosomes and Cancer

Year:

2006

Language:

english

File:

PDF, 206 KB

english, 2006

10

Somatic mutations of the mitochondrial genome in human breast cancers

Ling-Ming Tseng, Pen-Hui Yin, Chu-Wen Yang, Yi-Fang Tsai, Chih-Yi Hsu, Chin-Wen Chi, Hsin-Chen Lee

Journal:

Genes, Chromosomes and Cancer

Year:

2011

Language:

english

File:

PDF, 1.21 MB

english, 2011

11

Photoageing-associated mitochondrial DNA length mutations in human skin

Hsin-Chen Lee, Yau-Huei Wei, Jen-Hung Yang

Journal:

Archives of Dermatological Research

Year:

1995

Language:

english

File:

PDF, 1.06 MB

english, 1995

12

Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence

Hsin-Chen Lee, Pen-Hui Yin, Chin-Wen Chi, Yau-Huei Wei

Journal:

Journal of Biomedical Science

Year:

2002

Language:

english

File:

PDF, 1.95 MB

english, 2002

13

Mitochondrial role in life and death of the cell

Hsin-Chen Lee, Yau-Huei Wei

Journal:

Journal of Biomedical Science

Year:

2000

Language:

english

File:

PDF, 2.33 MB

english, 2000

14

Role of mitochondria in human aging

Hsin-Chen Lee, Yau-Huei Wei

Journal:

Journal of Biomedical Science

Year:

1997

Language:

english

File:

PDF, 1.21 MB

english, 1997

15

Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells

Sheng-Fan Wang, Jiin-Cherng Yen, Pen-Hui Yin, Chin-Wen Chi, Hsin-Chen Lee

Journal:

Year:

2008

Language:

english

File:

PDF, 681 KB

english, 2008

16

Mitochondrial DNA Content as a Potential Marker to Predict Response to Anthracycline in Breast Cancer Patients

Chih-Wei Hsu, Pen-Hui Yin, Hsin-Chen Lee, Chin-Wen Chi, Ling-Ming Tseng

Journal:

The Breast Journal

Year:

2010

Language:

english

File:

PDF, 190 KB

english, 2010

17

Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation

Chia-Fu Chang, Hui-Ju Huang, Hsin-Chen Lee, Kai-Chih Hung, Rong-Tsun Wu, Anya Maan-Yuh Lin

Journal:

Journal of Pineal Research

Year:

2012

Language:

english

File:

PDF, 578 KB

english, 2012

18

Oxidative Damage and Mutation to Mitochondrial DNA and Age-dependent Decline of Mitochondrial Respiratory Function

YAU-HUEI WEI, CHING-YOU LU, HSIN-CHEN LEE, CHENG-YOONG PANG, YI-SHING MA

Journal:

Annals of the New York Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 209 KB

english, 1998

19

Increases of Mitochondrial Mass and Mitochondrial Genome in Association with Enhanced Oxidative Stress in Human Cells Harboring 4,977 BP-Deleted Mitochondrial DNA

Yau-Huei Wei, Cheng-Feng Lee, Hsin-Chen Lee, Yi-Shing Ma, Chia-Wen Wang, Ching-You Lu, Cheng-Yoong Pang

Journal:

Annals of the New York Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 4.75 MB

english, 2001

20

Mitochondrial Genome Instability and mtDNA Depletion in Human Cancers

HSIN-CHEN LEE, PEN-HUI YIN, JIN-CHING LIN, CHENG-CHUNG WU, CHIH-YI CHEN, CHEW-WUN WU, CHIN-WEN CHI, TSENG-NIP TAM, YAU-HUEI WEI

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 680 KB

english, 2005

21

Age-dependent increase of mitochondrial DNA deletions together with lipid peroxides and superoxide dismutase in human liver mitochondria

Tzu-Chen Yen, Kwang-Liang King, Hsin-Chen Lee, Shin-Hwa Yeh, Yau-Huei Wei

Journal:

Free Radical Biology and Medicine

Year:

1994

Language:

english

File:

PDF, 661 KB

english, 1994

22

Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway

Li-Hsin Chen, Che-Chuan Loong, Tsann-Long Su, Yi-Jang Lee, Pei-Ming Chu, Ming-Long Tsai, Ping-Hsin Tsai, Pang-Hsien Tu, Chin-Wen Chi, Hsin-Chen Lee, Shih-Hwa Chiou

Journal:

Biochemical Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.76 MB

english, 2011

23

Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) upregulated E-cadherin expression in HepG2 cells

Hui-Ju Lee, Yeu Su, Wing-Yiu Lui, Gar-Yang Chau, Pen-Hui Yin, Hsin-Chen Lee, Chin-Wen Chi

Journal:

Year:

2008

Language:

english

File:

PDF, 1.33 MB

english, 2008

24

A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways

Kun-Ling Tsai, Yi-Hsiang Huang, Chung-Lan Kao, De-Ming Yang, Hsin-Chen Lee, Hsiang-Yun Chou, Yu-Chih Chen, Guang-Yuh Chiou, Li-Hsin Chen, Yi-Ping Yang, Tsan-Hung Chiu, Chiou-Sheng Tsai, Hsiu-Chung Ou,

Journal:

The Journal of Nutritional Biochemistry

Year:

2012

Language:

english

File:

PDF, 1.51 MB

english, 2012

25

Accumulation of mitochondrial DNA with 4977-bp deletion in knee cartilage – an association with idiopathic osteoarthritis

Ming-Chau Chang, Shih-Chieh Hung, Winby York-Kwan Chen, Tzu-Ling Chen, Cheng-Feng Lee, Hsin-Chen Lee, Kai-Li Wang, Chung-Chih Chiou, Yau-Huei Wei

Journal:

Osteoarthritis and Cartilage

Year:

2005

Language:

english

File:

PDF, 322 KB

english, 2005

26

Gly482Ser polymorphism in the peroxisome proliferator–activated receptor γ coactivator–1α gene is associated with oxidative stress and abdominal obesity

Shao-Wen Weng, Tsu-Kung Lin, Pei-Wen Wang, I-Ya Chen, Hsin-Chen Lee, Shang-Der Chen, Yao-Chung Chuang, Chia-Wei Liou

Journal:

Year:

2010

Language:

english

File:

PDF, 125 KB

english, 2010

27

Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma

Hsin-Chen Lee, Shu-Hui Li, Jin-Ching Lin, Cheng-Chung Wu, Dah-Cherg Yeh, Yau-Huei Wei

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2004

Language:

english

File:

PDF, 177 KB

english, 2004

28

Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease

Kuang-Den Chen, Po-Tsung Chang, Yueh-Hsin Ping, Hsin-Chen Lee, Chin-Wei Yeh, Pei-Ning Wang

Journal:

Neurobiology of Disease

Year:

2011

Language:

english

File:

PDF, 340 KB

english, 2011

29

Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis

Chi-Wei Wu, Yueh-Hsin Ping, Jiin-Cherng Yen, Chia-Yu Chang, Sheng-Fan Wang, Chiao-Ling Yeh, Chin-Wen Chi, Hsin-Chen Lee

Journal:

Toxicology and Applied Pharmacology

Year:

2007

Language:

english

File:

PDF, 400 KB

english, 2007

30

Exclusive Homoplasmic 11778 Mutation in Mitochondrial DNA of Chinese Patients With Leber’s Hereditary Optic Neuropathy

May-Yung Yen, Hsin-Chen Lee, An-Guor Wang, Wei-Ling Chang, Jorn-Hon Liu, Yau-Huei Wei

Journal:

Japanese Journal of Ophthalmology

Year:

1999

Language:

english

File:

PDF, 155 KB

english, 1999

31

Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin

Ching-You Lu, Hsin-Chen Lee, Huei-Jyh Fahn, Yau-Huei Wei

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1999

Language:

english

File:

PDF, 219 KB

english, 1999

32

Concurrent Increase of Oxidative DNA Damage and Lipid Peroxidation Together with Mitochondrial DNA Mutation in Human Lung Tissues During Aging—Smoking Enhances Oxidative Stress on the Aged Tissues

Hsin-Chen Lee, Maria L.R. Lim, Ching-You Lu, Vincent W.S. Liu, Huei-Jyh Fahn, Chunfang Zhang, Phillip Nagley, Yau-Huei Wei

Journal:

Archives of Biochemistry and Biophysics

Year:

1999

Language:

english

File:

PDF, 95 KB

english, 1999

33

Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle

Hsin-Chen Lee, Cheng-Yoong Pang, Hueih-Shing Hsu, Yau-Huei Weia

Journal:

Year:

1994

Language:

english

File:

PDF, 1.18 MB

english, 1994

34

Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer

Wen-Yi Hung, Chew-Wun Wu, Pen-Hui Yin, Chun-Ju Chang, Anna Fen-Yau Li, Chin-Wen Chi, Yau-Huei Wei, Hsin-Chen Lee

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2010

Language:

english

File:

PDF, 1.35 MB

english, 2010

35

Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells

Wen-Yi Hung, Kuo-Hung Huang, Chew-Wun Wu, Chin-Wen Chi, Hwa-Li Kao, Anna Fen-Yau Li, Pen-Hui Yin, Hsin-Chen Lee

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2012

Language:

english

File:

PDF, 1.13 MB

english, 2012

36

Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress

Hsin-Chen Lee, Yau-Huei Wei

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2005

Language:

english

File:

PDF, 195 KB

english, 2005

37

Polymorphisms of estrogen-metabolizing genes and risk of hepatocellular carcinoma in Taiwan females

Pen-Hui Yin, Hsin-Chen Lee, Gar-Yang Chau, Tsung-Yun Liu, Hsiu-Chih Liu, Wing-Yiu Lui, Chin-Wen Chi

Journal:

Year:

2004

Language:

english

File:

PDF, 126 KB

english, 2004

38

Peripheral blood mitochondrial DNA content and dysregulation of glucose metabolism

Shao-Wen Weng, Tsu-Kung Lin, Chia-Wei Liou, Shang-Der Chen, Yau-Huei Wei, Hsin-Chen Lee, I-Ya Chen, Ching-Jung Hsieh, Pei-Wen Wang

Journal:

Diabetes Research and Clinical Practice

Year:

2009

Language:

english

File:

PDF, 212 KB

english, 2009

39

Somatic mutations of mitochondrial genome in hepatocellular carcinoma

Pen-Hui Yin, Cheng-Chung Wu, Jin-Ching Lin, Chin-Wen Chi, Yau-Huei Wei, Hsin-Chen Lee

Journal:

Year:

2010

Language:

english

File:

PDF, 1.40 MB

english, 2010

40

Increased expression of manganese-superoxide dismutase in fibroblasts of patients with CPEO syndrome

Ching-You Lu, Edward K Wang, Hsin-Chen Lee, Huey-Jen Tsay, Yau-Huei Wei

Journal:

Molecular Genetics and Metabolism

Year:

2003

Language:

english

File:

PDF, 259 KB

english, 2003

41

Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung

Hsin-Chen Lee, Ching-You Lu, Huei-Jyh Fahn, Yau-Huei Wei

Journal:

Year:

1998

Language:

english

File:

PDF, 177 KB

english, 1998

42

Enhanced oxidative damage in human cells harboring A3243G mutation of mitochondrial DNA: implication of oxidative stress in the pathogenesis of mitochondrial diabetes

Cheng-Yoong Pang, Hsin-Chen Lee, Yau-Huei Wei

Journal:

Diabetes Research and Clinical Practice

Year:

2001

Language:

english

File:

PDF, 157 KB

english, 2001

43

Decreased cellular respiratory function and mitochondrial DNA mutations in the human heart associated with ageing and disease

Yau-Huei Wei, Hsin-Chen Lee, Edward K. Wang, Cheng-Yoong Pang

Journal:

The Asia Pacific Heart Journal

Year:

1997

Language:

english

File:

PDF, 1.01 MB

english, 1997

44

Accumulation of mitochondrial DNA deletions in human oral tissues — effects of betel quid chewing and oral cancer

Hsin-Chen Lee, Pen-Hui Yin, Tzu-Ning Yu, Yeong-Dar Chang, Wen-Chen Hsu, Shou-Yen Kao, Chin-Wen Chi, Tsung-Yun Liu, Yau-Huei Wei

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2001

Language:

english

File:

PDF, 181 KB

english, 2001

45

MELAS syndrome associated with diabetes mellitus and hyperthyroidism: a case report from Taiwan

Chwen-Yi Yang, Hing-Chung Lam, Hsin-Chen Lee, Yau-Huel Wei, Chlh-Chen Lu, Tlan-Mu Han, Jin-Llan Tsalt, Yen-Hwang Chuang, Jenn-Kuen Lee

Journal:

Clinical Endocrinology

Year:

1995

Language:

english

File:

PDF, 930 KB

english, 1995

46

Regulation of mitochondrial FoF1ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977 bp deletion of mitochondrial DNA

Yu-Ting Wu, Hsin-Chen Lee, Chen-Chung Liao, Yau-Huei Wei

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2013

Language:

english

File:

PDF, 718 KB

english, 2013

47

Tandem Duplications and Large-Scale Deletions of Mitochondrial DNA Are Early Molecular Events of Human Aging Process

YAU-HUEI WEI, CHENG-YOONG PANG, BAN-JAU YOU, HSIN-CHEN LEE

Journal:

Annals of the New York Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 874 KB

english, 1996

48

Simultaneous Increase of Mitochondrial DNA Deletions and Lipid Peroxidation in Human Aging

YAU-HUEI WEI, SHU-HUEI KAO, HSIN-CHEN LEE

Journal:

Annals of the New York Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 922 KB

english, 1996

49

Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways

Chu-Wen Yang, Chi-Lun Chang, Hsin-Chen Lee, Chin-Wen Chi, Jia-Ping Pan, Wen-Chin Yang

Journal:

BMC Complementary and Alternative Medicine

Year:

2012

Language:

english

File:

PDF, 768 KB

english, 2012

50

Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing

Lee, Hsin-Chen, Pang, Cheng-Yoong, Hsu, Hueih-Shing, Wei, Yau-Huei

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

1994

Language:

english

File:

PDF, 625 KB

english, 1994

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